Non-steroidal 抗炎药 (NSAIDs) reduced both antibody 和 inflammatory responses to SARS-CoV-2 infection in mice, according to a 在学习 病毒学杂志.  

这个调查 is important because “NSAIDs are arguably the most commonly 用过的 anti-inflammatory medications,” 说过 principal investigator Craig B. Wilen, Assistant Professor of Laboratory Medicine 和 Immunology, Yale University School of Medicine.  

除了服用 NSAIDs 对于诸如关节炎之类的慢性疾病,人们会在“感染期间以及[在]急性炎症期间,如COVID-19经历的较短时间内服用它们, and for side effects  from vaccination, such as soreness, fever, 和 malaise,” 威伦博士说。 “Our work 建议 the NSAID meloxicam dampens the immune response to SARS-CoV-2 infection.”  

这个调查 also suggests that the consequences of NSAID use during natural infection 和 vaccination should be evaluated in humans, 威伦博士说。 “This data likely exists, particularly in the clinical trials 对于 the vaccines, so it 应该开采出来,看看它是否会在人体内产生抗体反应。”  

“采取 COVID-19期间的NSAID could 是有害的还是有益的,取决于给药时间,” said Dr.Wilen. The potent anti-inflammatory, dexamethasone (非NSAID),不利于COVID-19病人 when taken 在感染初期, but beneficial when administered during later stages of 新冠肺炎, 威伦博士说。  

同样, 非甾体抗炎药的抗炎活性可能在早期就有害。 SARS-CoV-2 感染,因为在此阶段,炎症通常是有帮助的。这种情况会在COVID-19的后期改变,特别是如果患者接受了 强烈的炎症被称为细胞因子风暴。细胞因子风暴 is an immune response 的炎症化合物 often occurs 在COVID-19患者中, 会导致并发症,需要 重症监护病房,甚至死亡。 

A reduction in neutralizing antibodies caused by 非甾体抗炎药 might be benign, or it might blunt the immune system’s ability to fight the disease during the early stages of infection. It 可以 也 reduce the magnitude 和/or length of protection from either natural infection or vaccination, 威伦博士说。  

The initial motivation to investigate 非甾体抗炎药’ effect on 新冠肺炎 “was a twitter thread, suggesting 非甾体抗炎药 should not be used during 新冠肺炎,” 威伦博士说。 “This seemed suspicious to us, so we wanted to investigate.”  

威伦博士及其团队 预计NSAID对病毒感染几乎没有影响,事实证明是 correct.They 也认为NSAID不会显着 影响抗体对自然感染的反应。 “事实上,起初我们甚至没有仔细研究抗体反应,因为我们不希望它会被NSAID改变。事实证明这是错误的, said Dr. Wilen.